ATAD2 belongs to the family of AAA+ proteins, which are involved in a number of cellular processes ranging from protein degradation and DNA replication to membrane fusion and the movement of microtubule motors. AAA family proteins thereby often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The hallmark of AAA (ATPases Associated with diverse cellular Activities) proteins is a 200-250 amino –acid ATP-binding domain. Human ATAD2 consists of two AAA+ domains and 1 Bromo domain.
ATAD2 is a member of the AAA ATPase family. Contains a bromodomain, a domain known to interact specifically with acetylated lysine. Two alternatively spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.3; Hydrolase
Cellular Component: nucleolus; nucleus
Molecular Function: hydrolase activity; ATPase activity; nucleotide binding; ATP binding
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