Where to get MPDZ (7th)?

MPDZ (MUPP-1) is a large protein of 2042 amino acids that contains 13 individual PDZ domains. These domains bind to the C-terminal 4-5 residues of the target protein, localising the proteins to defined regions. The large number of PDZ domains in MPDZ allows the protein to form many connections with several different proteins thus helping to form the large protein scaffold assemblies found at tight junctions.
One of the identified binding partners of the 7th PDZ domain of MPDZ is the adenovirus E4-ORF1 that codes for an UTPase. This virus is known to play a role in tumor formation with the E4-ORF1 protein being identified as oncogenic. It is the specific interaction of the E4-ORF1 with MPDZ that causes cell proliferation as disruption of the MPDZ binding site prevents cell transformation. Hence, the 7th domain of MPDZ is targeted by the adenovirus E4-ORF1 whose function is important in controlling cellular proliferation.
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