What is Abl2+ K00546?

Abl2(also known as ARG (ABL Related Gene)) is a member of the Abelson family of non-receptor tyrosine kinase. ABL2 shares a high degree of sequence conservation with cABL and has similar domain organization comprising an N-terminal SH3–SH2 kinase domain unit followed by a C-terminal domain containing docking sites for SH3 domains, F-actin and microtubules. Through its interactions with the cytoskeleton Abl2 plays a role in murine neurulation and it is required for adhesion-dependent neurite branching and synapse/dendrite stability. ABL2 has also a role in fibroblastic- and epithelial cell adhesion and migration. ABL2 shares a number of cellular regulatory functions with cABL. Targeted disruption of the cAbl gene in mice resulted in pleiotropic phenotypes including runtedness, high perinatal lethality, susceptibility to infections, and immune deficiencies.
Like ABL1, Abl2 is involved in human neoplastic diseases. Abl is up- or down-regulated in several solid tumors and oncogenic gene translocations involving the ETV6 gene have been described in human acute leukemia. Previously we have describe the structure of the kinase domain of ABL2 at 2.05 ? resolution in complex with the oncology drug gleevec.
More about: Abl2+ K00546
Read more: Proteases Enzyme