2442 amino acids; 265351 Da; predict PI=8.83; Known domains are: KIX= CREB binding , Bromo= Bromodomain, Zn=zinc-finger (corresponding to cysteine-histidine rich regions), HAT= acetyl transferasic, Q= poly Glutaminic stretch. From the carboxy to the N-terminus: Q-Zn-HAT-Zn-Bromo-KIX-Zn. Reported isoform b (2402 aa) lacking aa406-444 (exon 5). Methylation of the KIX domain by CARM1 blocks association with CREB.
Function of CREBBP bromodomain
Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes;
Acts as transcription co-activator by: i) enabling the interaction between different TF and RNAPolII complexes, ii) serving as molecular scaffold that brings enzymes to the promoter, iii) remodelling the chromatin favouring the open status, by histone and non-histone proteins acetylation.
Essential role in embryogenesis, cell differentiation, apoptosis, and proliferation;
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